| Expression pattern: |
DN |
| Associated gene: |
TGIF2 |
| Associated microRNA: |
miR-605-5p |
| Biological function: |
inhibits prostate cancer cell proliferation, migration, tumor growth and metastasis |
| Molecular mechanism: |
acts as a miRNA sponge for miR-605-5p, derepresses TGIF2, and inactivates the TGF-beta pathway |
| Biological pathway or process: |
TGF-beta/SMAD (inhibits); proliferation (inhibits); migration (inhibits); metastasis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
H
M
|
| Validation methods: |
Microarray; RT-qPCR; RNase R Treatment; Sanger Sequencing; Actinomycin D / DRB Stability Assay; FISH / smFISH; Nuclear-Cytoplasmic Fractionation; RNA Pull-Down; Luciferase Reporter Assay; RNA-seq; Bioinformatics Analysis; Transfection; CCK8; Colony Formation Assay; Cell Cycle Assay; Transwell Assay; Wound Healing Assay; In Vivo Animal Model; H&E Staining; IHC (Immunohistochemistry); Clinical Sample Validation |
| Clinical significance: |
Downregulation of hsa_circ_0063329 was notably correlated with aggressive pT stage in patients with PCa. |
| Description: |
hsa_circ_0063329 is down-regulated in prostate cancer and functions as a tumor suppressor by inhibiting proliferation, migration, and in vivo tumor growth. It mainly localizes to the cytoplasm and sponges miR-605-5p, thereby upregulating TGIF2 and suppressing TGF-beta/SMAD signaling. |
| Confidence score: |
0.8671 |