circRNA basic information
circBase ID: hsa_circ_0001722
Name: -
Synonym: Circ_0001722 / circ_001722
Host Gene: -
Genomic location(hg19): chr7:90376995-90419967:+
Genomic location(hg38): chr7:90747680-90790652:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0009807
MONDO name: osteosarcoma
Disease details: Osteosarcoma / OS
Disease DO ID:
 3347
Disease MeSH ID:
 D012516
Disease NCIt ID:
 C9145
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

OS tissues; adjacent nontumor tissue
Cell lines:

MG63; U2OS; hFOB1.19; HEK293T
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: RUNX2, AGO2
Associated microRNA: miR-204-5p
Biological function: Promotes proliferation and invasion (metastasis) of osteosarcoma cells; promotes tumorigenesis in vivo.
Molecular mechanism: Acts as a miRNA sponge for miR-204-5p, thereby relieving miR-204-5p-mediated repression of RUNX2.
Biological pathway or process:

proliferation (promotes); invasion (promotes); metastasis (promotes); ceRNA regulation (promotes)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; RNase R Treatment; divergent primers PCR; Sanger Sequencing; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; MTT; Transwell Assay; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry); Bioinformatics Analysis
Clinical significance:

-
Description:

circ_0001722 (circ_001722) is up-regulated in osteosarcoma tissues/cells and functions as an oncogenic circRNA by sponging miR-204-5p, thereby relieving repression of RUNX2 and promoting osteosarcoma cell proliferation and invasion in vitro and tumor growth in vivo.
Confidence score:

0.8267
Other information
Title:

A novel CircRNA Circ_0001722 regulates proliferation and invasion of osteosarcoma cells through targeting miR-204-5p/RUNX2 axis.

Journal: Journal of cancer research and clinical oncology
Published: 2023
PubMed ID: 37453970
Study type:

combined biological and clinical study
Data availability: 10.1007/s00432-023-05166-3
Code availability: -