circRNA basic information
circBase ID: hsa_circ_0054843
Name: hsa_circ_USP34
Synonym: hsa_circ_00054843
Host Gene: USP34
Genomic location(hg19): chr2:61577394-61577828:-
Genomic location(hg38): chr2:61350259-61350693:-
Subcellular localization: exosome
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0013792
MONDO name: intracerebral hemorrhage
Disease details: hypertensive intracerebral hemorrhage
Disease DO ID:
 -
Disease MeSH ID:
 D002543
Disease NCIt ID:
 -
Disease ICD11 ID:
 873092535
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

plasma; peripheral blood
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: NEDD4L
Associated microRNA: miR-3610-3p
Biological function: May promote NEDD4L expression by suppressing miR-3610-3p and contribute to lower GCS score in HICH patients.
Molecular mechanism: Predicted ceRNA mechanism: hsa_circ_00054843/miR-3610-3p/NEDD4L.
Biological pathway or process:

ceRNA regulation (other); inflammation (promotes); macrophage polarization (promotes); immune regulation (promotes)
Detected method:
M
Validation methods:

Microarray; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

Associated with bleeding volume and GCS score; proposed as a target for prognosis and intervention of HICH.
Description:

hsa_circ_0054843, also referred to in the discussion as hsa_circ_00054843, is an up-regulated plasma exosomal circRNA in HICH. The paper predicts that it may act through a miR-3610-3p/NEDD4L ceRNA axis and may be relevant to hypertension-related etiology, inflammation, and clinical severity.
Confidence score:

0.348
Other information
Title:

Signature and function of plasma exosome-derived circular RNAs in patients with hypertensive intracerebral hemorrhage.

Journal: Molecular genetics and genomics : MGG
Published: 2024
PubMed ID: 38734849
Study type:

clinical bioinformatics study
Data availability: Data available on request from the authors.
Code availability: -