circRNA basic information
circBase ID: -
Name: hsa_circ_FAT1
Synonym: circFAT1
Host Gene: FAT1
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005575
MONDO name: colorectal cancer
Disease details: colorectal cancer / CRC
Disease DO ID:
 5672, 9256
Disease MeSH ID:
 -
Disease NCIt ID:
 C4978
Disease ICD11 ID:
 -
Disease OMIM ID:
 114500
Species: Human
Species details: Homo sapiens
Tissue specimen:

CRC tissues; adjacent normal tissues
Cell lines:

CCC-HIE-2; HCT116; SW837; SW480; LOVO; SW620
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: UHRF1
Associated microRNA: miR-520b, miR-302c-3p
Biological function: circFAT1 promotes CRC cell proliferation, cell cycle progression, glycolysis and tumor growth, and inhibits apoptosis; circFAT1 knockdown suppresses CRC cell proliferation, cycle and glycolysis, induces apoptosis, and represses tumor growth in vivo.
Molecular mechanism: circFAT1 acts as a sponge for miR-520b and miR-302c-3p, thereby upregulating UHRF1 and affecting CRC cell proliferation, apoptosis and glycolysis.
Biological pathway or process:

ceRNA regulation (promotes); proliferation (promotes); cell cycle (promotes); apoptosis (inhibits); glycolysis (promotes)
Detected method:
Q
Validation methods:

RNase R Treatment; RT-qPCR; Clinical Sample Validation; Transfection; MTT; Cell Cycle Assay; Annexin V/PI Flow Cytometry; Western Blot; Luciferase Reporter Assay; Bioinformatics Analysis; In Vivo Animal Model
Clinical significance:

-
Description:

circFAT1 is up-regulated in colorectal cancer tissues and cell lines and functions as an oncogenic circRNA. It promotes CRC cell proliferation, cell cycle progression, glycolysis and xenograft tumor growth while inhibiting apoptosis, mainly through sponging miR-520b and miR-302c-3p to increase UHRF1 expression.
Confidence score:

0.7177
Other information
Title:

CircFAT1 Suppresses Colorectal Cancer Development Through Regulating miR-520b/UHRF1 Axis or miR-302c-3p/UHRF1 Axis.

Journal: Cancer biotherapy & radiopharmaceuticals
Published: 2021
PubMed ID: 32379550
Study type:

combined biological and clinical study
Data availability: The analyzed data sets generated during the present study are available from the corresponding author on reasonable request.
Code availability: -