| Expression pattern: |
UP |
| Associated gene: |
ZNF281, Ago2 |
| Associated microRNA: |
miR-203 |
| Biological function: |
Promotes NSCLC cell proliferation, invasion, migration, EMT and metastasis. |
| Molecular mechanism: |
Acts as a ceRNA/miRNA sponge for miR-203, thereby relieving miR-203-mediated repression of ZNF281. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); EMT (promotes); metastasis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Transwell Assay; Luciferase Reporter Assay; RNA Pull-Down; RIP (RNA Immunoprecipitation); Western Blot; Bioinformatics Analysis |
| Clinical significance: |
Potential diagnostic, prognostic and therapeutic target for NSCLC. |
| Description: |
circAGFG1 is up-regulated in NSCLC tissues and promotes proliferation, invasion, migration, and EMT. It functions as a ceRNA by sponging miR-203, thereby increasing ZNF281 expression and facilitating NSCLC growth and metastasis. |
| Confidence score: |
0.7244 |