| Expression pattern: |
UP |
| Associated gene: |
TAZ |
| Associated microRNA: |
miR-345-3p |
| Biological function: |
Promotes retinal vascular dysfunction and endothelial angiogenic behaviors (proliferation, migration, invasion) under diabetic/high-glucose conditions; increases VEGF and inflammatory/oxidative stress factors. |
| Molecular mechanism: |
Acts as a ceRNA/miRNA sponge for miR-345-3p, relieving miR-345-3p-mediated repression of TAZ and increasing TAZ levels, leading to vascular dysfunction (with VEGF involvement). |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); angiogenesis (promotes); inflammation (promotes); oxidative stress (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Nuclear-Cytoplasmic Fractionation; Sanger Sequencing; Back-Splice Junction PCR / divergent primers PCR; FISH / smFISH; RIP (RNA Immunoprecipitation); RNA Pull-Down; Luciferase Reporter Assay; Transfection; MTT; EdU Staining; Transwell Assay; Wound Healing Assay; Western Blot; ELISA; In Vivo Animal Model; Bioinformatics Analysis; Clinical Sample Validation; Cohort Study |
| Clinical significance: |
circRSU1 is overexpressed in DR patients and is positively associated with poor prognosis; proposed as a potential therapeutic target. |
| Description: |
circRSU1 is upregulated in diabetic retinopathy and in high-glucose-treated HRVECs. It promotes endothelial proliferation/migration/invasion and retinal vascular dysfunction by sponging miR-345-3p and increasing TAZ expression, with downstream increases in VEGF and inflammatory/oxidative stress responses. |
| Confidence score: |
0.8817 |