circRNA basic information
circBase ID: -
Name: hsa_circ_BBS9
Synonym: circRNA BBS9 / circRNA-BBS9
Host Gene: BBS9
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005002
MONDO name: chronic obstructive pulmonary disease
Disease details: chronic obstructive pulmonary disease / COPD
Disease DO ID:
 3083
Disease MeSH ID:
 D029424
Disease NCIt ID:
 C3199
Disease ICD11 ID:
 133207228
Disease OMIM ID:
 606963
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

HPMECs; 293T
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: BCL2L13
Associated microRNA: miRNA-103a-3p
Biological function: Promotes CSE-induced apoptosis in HPMECs (pro-apoptotic role in the COPD cell model).
Molecular mechanism: Acts as a miRNA sponge for miRNA-103a-3p, thereby relieving miRNA-103a-3p-mediated repression of BCL2L13 and promoting apoptosis.
Biological pathway or process:

apoptosis (promotes); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Luciferase Reporter Assay; Transfection; Annexin V/PI Flow Cytometry; Western Blot; ELISA; Bioinformatics Analysis
Clinical significance:

-
Description:

circRNA BBS9 is up-regulated in a CSE-induced COPD cell model and promotes endothelial cell apoptosis. Mechanistically, it sponges miRNA-103a-3p to derepress the downstream target BCL2L13, forming a circRNA BBS9/miRNA-103a-3p/BCL2L13 axis that drives apoptosis.
Confidence score:

0.5554
Other information
Title:

Significant role of circRNA BBS9 in chronic obstructive pulmonary disease via miRNA-103a-3p/BCL2L13.

Journal: BMC pulmonary medicine
Published: 2023
PubMed ID: 37442983
Study type:

biological research
Data availability: The datasets used and/or analyzed during the present study are available from the corresponding author on reasonable request.
Code availability: -