| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
miR-1287-5p |
| Biological function: |
promotes proliferation, migration, invasion and tumor growth; inhibits apoptosis; has diagnostic value for NSCLC |
| Molecular mechanism: |
exosomal circ_0048856 promotes NSCLC development by directly targeting and downregulating miR-1287-5p |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Western Blot; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; MTT; Annexin V/PI Flow Cytometry; Transwell Assay; In Vivo Animal Model; ROC Analysis |
| Clinical significance: |
exosome derived circ_0048856 had high diagnostic value for NSCLC with AUC 0.943, sensitivity 0.880 and specificity 0.800 |
| Description: |
Exosomal circ_0048856 is up-regulated in NSCLC serum exosomes and NSCLC cell lines. It promotes NSCLC progression by enhancing proliferation, migration, invasion and in vivo tumor growth while inhibiting apoptosis, at least partly through direct targeting and downregulation of miR-1287-5p. Serum exosomal circ_0048856 also shows diagnostic potential for NSCLC. |
| Confidence score: |
0.7126 |