| Expression pattern: |
UP |
| Associated gene: |
cyclin D1, c-MYC |
| Associated microRNA: |
miR-326-3p |
| Biological function: |
promotes proliferation and invasion; promotes cell cycle progression (increases G2/M entry) in gastric cancer cells |
| Molecular mechanism: |
acts as a miRNA sponge binding miR-326-3p; miR-326-3p inhibition rescues the phenotypes caused by hsa_circ_0000467 knockdown; regulates cyclin D1 expression |
| Biological pathway or process: |
proliferation (promotes); invasion (promotes); cell cycle (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Transwell Assay; Cell Cycle Assay; Luciferase Reporter Assay; Western Blot; Bioinformatics Analysis |
| Clinical significance: |
higher expression correlates with gastric cancer histological grade; potential diagnostic marker and therapeutic target |
| Description: |
hsa_circ_0000467 is up-regulated in gastric cancer tissues and cell lines and promotes GC cell proliferation, invasion, and cell-cycle progression. Mechanistically, it sponges miR-326-3p and affects cyclin D1 expression, and miR-326-3p inhibition rescues the effects of hsa_circ_0000467 knockdown. |
| Confidence score: |
0.6815 |