circRNA basic information
circBase ID: hsa_circ_0006646
Name: hsa_circ_BACH1
Synonym: hsa_ circBACH1_ 012
Host Gene: BACH1
Genomic location(hg19): chr8:141889569-141900868:-
Genomic location(hg38): chr8:140879470-140890769:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0019086
MONDO name: carcinoma of esophagus
Disease details: oesophageal cancer
Disease DO ID:
 1107
Disease MeSH ID:
 -
Disease NCIt ID:
 C3513
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

tumour tissue; normal oesophageal tissue
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: IL11, MFAP2, MMP10, MMP1
Associated microRNA: hsa-miR-4708-3p, hsa-miR-4778-3p, hsa-miR-4778-5p, hsa-miR-3180-5p, hsa-miR-425-5p, hsa-miR-5589-3p, hsa-miR-6888-3p, hsa-miR-4743-3p, hsa-miR-488-3p, hsa-miR-7161-3p, hsa-miR-130a-5p, hsa-miR-4712-5p, hsa-miR-770-5p, hsa-miR-548ae-3p, hsa-miR-548ah-3p, has-miR-548aq-3p, hsa-miR-548j-3p, hsa-miR-7155-5p
Biological function: Promotes EMT process in oesophageal cancer (via relieving miRNA-mediated inhibition of EMT-related genes).
Molecular mechanism: QKI-regulated circRNA biogenesis and ceRNA mechanism: hsa_circ_0006646 sponges multiple miRNAs to de-repress IL11/MFAP2/MMP10/MMP1, promoting EMT.
Biological pathway or process:

EMT (promotes); ceRNA regulation (promotes)
Detected method:
S
Validation methods:

RNA-seq; Bioinformatics Analysis
Clinical significance:

-
Description:

In oesophageal cancer, hsa_circ_0006646 (from host gene BACH1) is predicted to be upregulated and promoted by QKI-regulated alternative splicing. It may act as a ceRNA by binding multiple miRNAs, thereby de-repressing EMT-related genes (IL11, MFAP2, MMP10, MMP1) and promoting EMT.
Confidence score:

0.1768
Other information
Title:

The possible molecular mechanism underlying the involvement of the variable shear factor QKI in the epithelial-mesenchymal transformation of oesophageal cancer.

Journal: PloS one
Published: 2023
PubMed ID: 37428781
Study type:

bioinformatics study
Data availability: GSE189830; TCGA-ESCA; GTEx; TCGASpliceSeq
Code availability: https://github.com/06cys2023/plos-one