circRNA basic information
circBase ID: hsa_circ_0003793
Name: hsa_circ_ZEB1
Synonym: ZEB1‐circRNA
Host Gene: ZEB1
Genomic location(hg19): chr10:31661946-31676727:+
Genomic location(hg38): chr10:31373017-31387798:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0018881
MONDO name: myelodysplastic syndrome
Disease details: Myelodysplastic syndrome / MDS
Disease DO ID:
 0050908
Disease MeSH ID:
 -
Disease NCIt ID:
 C3247
Disease ICD11 ID:
 -
Disease OMIM ID:
 614286
Species: Human
Species details: Homo sapiens
Tissue specimen:

bone marrow CD34+ cells
Cell lines:

NALM6
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: -
Molecular mechanism: -
Biological pathway or process:

not specified
Detected method:
S
Validation methods:

RNA-seq; RNase R Treatment; Sanger Sequencing
Clinical significance:

-
Description:

hsa_circ_0003793 is a ZEB1-derived circRNA up-regulated in SF3B1-mutated MDS (identified by RNA-seq), and its circular back-splice junction was experimentally confirmed (Sanger sequencing) as part of validating upregulated ZEB1 circular transcripts.
Confidence score:

0.385
Other information
Title:

Expression of circular RNAs in myelodysplastic neoplasms and their association with mutations in the splicing factor gene SF3B1.

Journal: Molecular oncology
Published: 2023
PubMed ID: 37408496
Study type:

combined biological and clinical study
Data availability: BioProject ID PRJNA896500
Code availability: -