| Expression pattern: |
UP |
| Associated gene: |
DNMT1, CDH13, DNMT1 3′-UTR |
| Associated microRNA: |
miR-142-5p |
| Biological function: |
Promotes ovarian tumor growth and ovarian cancer cell proliferation, migration, and invasion; silencing suppresses these malignant phenotypes. |
| Molecular mechanism: |
hsa_circ_0000119 acts as a miR-142-5p sponge, promotes DNMT1 expression, induces CDH13 promoter methylation, and reduces CDH13 expression to facilitate ovarian cancer progression. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); ceRNA regulation (promotes); other pathway/process (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; MTT; Colony Formation Assay; Transwell Assay; Luciferase Reporter Assay; Sanger Sequencing; Western Blot; In Vivo Animal Model; Bioinformatics Analysis |
| Clinical significance: |
Potential target for the treatment of ovarian cancer. |
| Description: |
hsa_circ_0000119 is up-regulated in ovarian cancer tissues and cell lines. It promotes tumor growth and ovarian cancer cell proliferation, migration, and invasion by sponging miR-142-5p, thereby increasing DNMT1 expression and enhancing CDH13 methylation/repression. The study proposes hsa_circ_0000119 as a potential therapeutic target for ovarian cancer. |
| Confidence score: |
0.7177 |