| Expression pattern: |
UP |
| Associated gene: |
KAT6B |
| Associated microRNA: |
miR‐506‐3p |
| Biological function: |
promotes cell proliferation; promotes migration; promotes epithelial-mesenchymal transition (EMT) |
| Molecular mechanism: |
Acts as a miRNA sponge (ceRNA) for miR-506-3p to regulate KAT6B expression. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); EMT (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; MTT; Colony Formation Assay; Wound Healing Assay; Western Blot |
| Clinical significance: |
circ‐MALAT1 could act as a potential therapeutic target for the treatment of colorectal cancer. |
| Description: |
circ‐MALAT1 is up-regulated in CRC tissues and CRC cell lines. It promotes CRC cell proliferation, migration and EMT by sponging miR-506-3p to increase KAT6B expression, with functional rescue by miR-506-3p inhibition or KAT6B overexpression. |
| Confidence score: |
0.6521 |