| Expression pattern: |
UP |
| Associated gene: |
proteolipid protein 2 (PLP2) |
| Associated microRNA: |
miR-422a |
| Biological function: |
promotes proliferation, migration, and invasion of ovarian carcinoma cells; promotes OC progression via exosome-mediated intercellular communication |
| Molecular mechanism: |
ceRNA mechanism: Foxo3 sponges miR-422a, relieving repression of PLP2; exosome-mediated transfer of Foxo3 between OC cells |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; FISH / smFISH; Nuclear-Cytoplasmic Fractionation; Luciferase Reporter Assay; Western Blot; Bioinformatics Analysis; Transfection; CCK8; Wound Healing Assay; Transwell Assay |
| Clinical significance: |
Foxo3 may serve as a potential biomarker for OC. |
| Description: |
Foxo3 is up-regulated in ovarian carcinoma cell lines and promotes proliferation, migration, and invasion. Mechanistically, Foxo3 acts as a miRNA sponge for miR-422a to increase PLP2 expression, and it can be transferred via exosomes to enhance OC progression. |
| Confidence score: |
0.6157 |