circRNA basic information
circBase ID: hsa_circ_0001326
Name: hsa_circ_PHLDB2
Synonym: hsa_circRNA_0001326
Host Gene: PHLDB2
Genomic location(hg19): chr3:111632165-111639266:+
Genomic location(hg38): chr3:111913318-111920419:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005233
MONDO name: non-small cell lung carcinoma
Disease details: non-small cell lung cancer / NSCLC
Disease DO ID:
 3908
Disease MeSH ID:
 D002289
Disease NCIt ID:
 C2926
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

serum
Cell lines:

A549
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: -
Molecular mechanism: -
Biological pathway or process:

not specified
Detected method:
Q
S
Validation methods:

divergent primers PCR; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

hsa_circRNA_0001326 is significantly down-regulated in the serum of NSCLC patients compared to healthy volunteers.
Description:

hsa_circRNA_0001326 (from host gene PHLDB2) is down-regulated in serum of NSCLC patients versus healthy volunteers. In PD-treated A549 cells, its expression increases, indicating it is PD-responsive and may be involved in PD-associated regulatory changes in NSCLC cells.
Confidence score:

0.5841
Other information
Title:

Whole Transcriptome Analysis Identifies Platycodin D-Mediated RNA Regulatory Network in Non-Small-Cell Lung Cancer.

Journal: Cells
Published: 2022
PubMed ID: 35954204
Study type:

combined biological and clinical study
Data availability: Please contact the corresponding author for all data requests.
Code availability: -