| Expression pattern: |
UP |
| Associated gene: |
LDHA, Ago2 |
| Associated microRNA: |
miR-520h |
| Biological function: |
Promotes glycolysis metabolism, proliferation, migration, and invasion, and inhibits apoptosis in OSCC; promotes tumor growth in vivo. |
| Molecular mechanism: |
Acts as a ceRNA/miRNA sponge for miR-520h to modulate LDHA expression. |
| Biological pathway or process: |
glycolysis (promotes); proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; divergent primers PCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; MTT; EdU Staining; Annexin V/PI Flow Cytometry; Transwell Assay; Wound Healing Assay; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry); Clinical Sample Validation; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
High level of circNFATC3 was correlated with lower overall survival. |
| Description: |
circNFATC3 is up-regulated in OSCC tissues/cells and functions as an oncogenic circRNA. It promotes glycolysis, proliferation, migration and invasion and inhibits apoptosis by sponging miR-520h to de-repress LDHA; circNFATC3 knockdown suppresses xenograft tumor growth in vivo. |
| Confidence score: |
0.8593 |