| Expression pattern: |
UP |
| Associated gene: |
SOX4 |
| Associated microRNA: |
miR-1253 |
| Biological function: |
Promotes prostate cancer cell viability, proliferation, invasion, tumor growth and radioresistance; suppresses apoptosis. |
| Molecular mechanism: |
Acts as a miRNA sponge for miR-1253 to increase SOX4 expression (ceRNA-like mechanism), thereby promoting malignant phenotypes and radioresistance. |
| Biological pathway or process: |
proliferation (promotes); invasion (promotes); apoptosis (inhibits); radioresistance (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Survival Analysis; Transfection; Luciferase Reporter Assay; Western Blot; MTT; EdU Staining; Annexin V/PI Flow Cytometry; Transwell Assay; Colony Formation Assay; IHC (Immunohistochemistry); In Vivo Animal Model |
| Clinical significance: |
High circ-ABCC4 abundance is associated with advanced stage, lymph node metastasis, and lower survival rate, suggesting it may be a prognostic factor in PCa. |
| Description: |
circ-ABCC4 is up-regulated in prostate cancer tissues and cell lines and promotes malignant progression and radioresistance while inhibiting apoptosis. Mechanistically, circ-ABCC4 sponges miR-1253 to increase SOX4 expression, forming a circ-ABCC4/miR-1253/SOX4 regulatory axis associated with poor patient survival. |
| Confidence score: |
0.7221 |