| Expression pattern: |
UP |
| Associated gene: |
MET |
| Associated microRNA: |
microRNA-34a |
| Biological function: |
Promotes proliferative ability and migration of gastric cancer cells. |
| Molecular mechanism: |
Circ-DB acts as a microRNA-34a sponge and regulates MET expression through the circ-DB-microRNA-34a-MET pathway. |
| Biological pathway or process: |
ceRNA regulation (other); proliferation (promotes); migration (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Nuclear-Cytoplasmic Fractionation; Luciferase Reporter Assay; Transfection; Transwell Assay; Western Blot |
| Clinical significance: |
Circ-DB was significantly overexpressed in GCa tissues and was significantly highly expressed in tumor samples with diameter ≥ 5 cm. |
| Description: |
Circ-DB is up-regulated in gastric cancer tissues and cell lines. It mainly localizes to the cytoplasm, binds microRNA-34a, and regulates MET expression through the circ-DB-microRNA-34a-MET axis. Functionally, circ-DB promotes proliferative ability and migration of gastric cancer cells and is associated with larger tumor diameter. |
| Confidence score: |
0.6429 |