circRNA basic information
circBase ID: hsa_circ_0058246
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): chr2:219305444-219305585:+
Genomic location(hg38): chr2:218440721-218440862:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0001056
MONDO name: gastric cancer
Disease details: gastric cancer / GC
Disease DO ID:
 10534
Disease MeSH ID:
 -
Disease NCIt ID:
 C9331
Disease ICD11 ID:
 1397617262
Disease OMIM ID:
 613659
Species: Human
Species details: Homo sapiens
Tissue specimen:

advanced gastric adenocarcinoma tissues; adjacent normal mucosa tissues; tumor specimens; advanced gastric cancer and corresponding adjacent tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: Associated with poor clinical outcomes, lymph node invasion, and recurrence in advanced gastric cancer; predicted to participate in circRNA-miRNA regulatory networks relevant to gastric cancer tumorigenesis, metastasis, and recurrence.
Molecular mechanism: Predicted circRNA-miRNA sponge/ceRNA-related regulatory mechanism based on TargetScan and circRNA-miRNA interaction network analysis.
Biological pathway or process:

ceRNA regulation (other); metastasis (promotes); other pathway/process (other)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; Clinical Sample Validation; Cohort Study; Bioinformatics Analysis
Clinical significance:

Elevated expression was observed in tumor specimens of patients with poor clinical outcomes; higher expression was associated with more than 16 lymph node invasions and recurrence of gastric cancer.
Description:

hsa_circ_0058246 was identified in this study as an up-regulated circRNA in advanced gastric cancer specimens and was validated by real-time PCR. Its elevated expression was associated with poor clinical outcomes, greater lymph node invasion, and recurrence, suggesting potential clinical relevance in advanced gastric cancer progression.
Confidence score:

0.5047
Other information
Title:

Circular RNAs play an important role in late-stage gastric cancer: Circular RNA expression profiles and bioinformatics analyses.

Journal: Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine
Published: 2017
PubMed ID: 28639908
Study type:

combined biological and clinical study
Data availability: -
Code availability: -