| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
hsa-let-7, hsa-miR-27a-3p, hsa-miR-432-5p, hsa-miR-513c-5p, hsa-miR-622, hsa-miR-548, hsa-miR-128, hsa-miR-27a |
| Biological function: |
may play key roles in EGFR-TKI resistance; potential biomarker for therapeutic monitoring |
| Molecular mechanism: |
predicted circRNA-miRNA interaction network (ceRNA-like implication, not experimentally validated) |
| Biological pathway or process: |
PI3K/AKT (other); ceRNA regulation (other); drug resistance (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Bioinformatics Analysis; Clinical Sample Validation |
| Clinical significance: |
candidate biomarker for EGFR-TKIs resistance monitoring in NSCLC/LUAD |
| Description: |
hsa_circ_0040348 is up-regulated in peripheral plasma from LUAD/NSCLC patients with acquired gefitinib resistance. It was selected from microarray DECs, included in a predicted circRNA-miRNA network related to PI3K-Akt signaling, and proposed as a candidate liquid-biopsy biomarker for EGFR-TKI resistance monitoring. |
| Confidence score: |
0.4032 |