circRNA basic information
circBase ID: hsa_circ_0003220
Name: hsa_circ_TMCO7
Synonym: -
Host Gene: TMCO7
Genomic location(hg19): chr16:68893786-68896964:+
Genomic location(hg38): chr16:68859883-68863061:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005233
MONDO name: non-small cell lung carcinoma
Disease details: non-small cell lung cancer / NSCLC
Disease DO ID:
 3908
Disease MeSH ID:
 D002289
Disease NCIt ID:
 C2926
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

NSCLC tissues; matched noncancerous counterparts
Cell lines:

H460; A549; H460/PTX; A549/PTX; 293T; HBE
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: IGF1, Ago2
Associated microRNA: miR-489-3p
Biological function: Promotes chemoresistance (PTX/DDP/DTX resistance) and proliferation in paclitaxel-resistant NSCLC cells.
Molecular mechanism: Acts as a ceRNA by sponging miR-489-3p to increase IGF1 expression, thereby enhancing chemoresistance.
Biological pathway or process:

chemoresistance (promotes); proliferation (promotes); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Survival Analysis; Transfection; MTT; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); ELISA
Clinical significance:

High hsa_circ_0003220 expression is associated with shorter overall survival in NSCLC patients.
Description:

hsa_circ_0003220 is up-regulated in paclitaxel-resistant NSCLC tissues and cell lines and promotes proliferation and resistance to PTX/DDP/DTX. Mechanistically, it sponges miR-489-3p to increase IGF1 expression (miR-489-3p/IGF1 axis). High hsa_circ_0003220 expression correlates with shorter overall survival in NSCLC patients.
Confidence score:

0.7238
Other information
Title:

Hsa_circ_0003220 Drives Chemoresistance of Human NSCLC Cells by Modulating miR-489-3p/IGF1.

Journal: International journal of genomics
Published: 2023
PubMed ID: 37361693
Study type:

combined biological and clinical study
Data availability: available from the corresponding author upon request
Code availability: -