| Expression pattern: |
UP |
| Associated gene: |
EIF4A1 |
| Associated microRNA: |
miR-599 |
| Biological function: |
promotes cell proliferation/growth and inhibits apoptosis and ferroptosis in gastric cancer; promotes tumorigenesis in vivo |
| Molecular mechanism: |
ceRNA mechanism: circ_0008035 sponges miR-599 to up-regulate EIF4A1 |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); ferroptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Nuclear-Cytoplasmic Fractionation; Luciferase Reporter Assay; Bioinformatics Analysis; Transfection; MTT; Western Blot; Annexin V/PI Flow Cytometry; In Vivo Animal Model; Survival Analysis; Clinical Sample Validation |
| Clinical significance: |
Overall survival of GC patients in High circ_0008035 group was significantly lower than in Low circ_0008035 group. |
| Description: |
circ_0008035 is up-regulated in gastric cancer tissues/cells and mainly localized in the cytoplasm. It promotes GC cell proliferation and tumor growth while inhibiting apoptosis and ferroptosis by sponging miR-599 to increase EIF4A1 expression, and high circ_0008035 is associated with worse overall survival. |
| Confidence score: |
0.7357 |