circRNA basic information
circBase ID: hsa_circ_0005085
Name: hsa_circ_ASAP2
Synonym: hsa_circRNA_102612 / circ_0005085
Host Gene: ASAP2
Genomic location(hg19): chr2:9419445-9437574:+
Genomic location(hg38): chr2:9279316-9297445:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0002529
MONDO name: skin squamous cell carcinoma
Disease details: cutaneous squamous cell carcinoma / CSCC
Disease DO ID:
 3151
Disease MeSH ID:
 -
Disease NCIt ID:
 C4819
Disease ICD11 ID:
 1448983042
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

CSCC tissues; normal tissues; tumor tissue
Cell lines:

HSC-1; A431; HaCaT; 293T
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
DN
Associated gene: LAMC1
Associated microRNA: miR-186-5p
Biological function: Inhibits CSCC cell proliferation, migration, invasion and EMT; promotes apoptosis; suppresses tumor growth in vivo.
Molecular mechanism: Acts as a ceRNA/miRNA sponge for miR-186-5p to regulate LAMC1 expression (hsa_circ_0005085/miR-186-5p/LAMC1 axis).
Biological pathway or process:

proliferation (inhibits); migration (inhibits); invasion (inhibits); EMT (inhibits); apoptosis (promotes); ceRNA regulation (other)
Detected method:
Q
M
Validation methods:

Microarray; Bioinformatics Analysis; RT-qPCR; RNase R Treatment; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; CCK8; Colony Formation Assay; EdU Staining; Transwell Assay; Annexin V/PI Flow Cytometry; Western Blot; IHC (Immunohistochemistry); In Vivo Animal Model; Clinical Sample Validation
Clinical significance:

-
Description:

hsa_circ_0005085 is down-regulated in CSCC and functions as a tumor suppressor. It sponges miR-186-5p to relieve repression of LAMC1, thereby inhibiting proliferation, migration/invasion and EMT while promoting apoptosis, and it suppresses xenograft tumor growth via the miR-186-5p/LAMC1 axis.
Confidence score:

0.8175
Other information
Title:

Hsa_circ_0005085 may suppress cutaneous squamous cell carcinoma growth and metastasis through targeting the miR-186-5p/LAMC1 axis.

Journal: Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)
Published: 2023
PubMed ID: 37357644
Study type:

combined biological and clinical study
Data availability: GSE74758
Code availability: -