circRNA basic information
circBase ID: hsa_circ_0007364
Name: hsa_circ_PTP4A2
Synonym: circPTP4A2
Host Gene: PTP4A2
Genomic location(hg19): chr1:32381495-32385259:-
Genomic location(hg38): chr1:31915894-31919658:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 1060198
MONDO name: ischemic stroke
Disease details: ischemic stroke / IS
Disease DO ID:
 -
Disease MeSH ID:
 -
Disease NCIt ID:
 -
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

plasma
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: Biomarker associated with stroke severity, TOAST subtypes, and prognosis (dynamic changes predict unfavorable outcome).
Molecular mechanism: Not established; authors speculate possible release into circulation after blood-brain barrier disruption and potential link to immune-inflammation.
Biological pathway or process:

not specified
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Cohort Study; ROC Analysis; Bioinformatics Analysis
Clinical significance:

Increased plasma circPTP4A2 is associated with AIS severity and stroke subtypes; changes within 7 days predict unfavorable 90-day outcome.
Description:

Plasma circPTP4A2 is up-regulated in AIS patients and higher levels are associated with greater stroke severity (NIHSS) and certain TOAST subtypes (notably LAA). Baseline levels are not predictive of outcome, but the 7-day change in circPTP4A2 helps predict unfavorable 90-day functional outcome.
Confidence score:

0.5121
Other information
Title:

Increased plasma levels of circPTP4A2 and circTLK2 are associated with stroke injury.

Journal: Annals of clinical and translational neurology
Published: 2023
PubMed ID: 37350305
Study type:

clinical study
Data availability: -
Code availability: -