circRNA basic information
circBase ID: hsa_circ_0023919
Name: hsa_circ_PICALM
Synonym: circ-0023919
Host Gene: PICALM
Genomic location(hg19): chr11:85707868-85714494:-
Genomic location(hg38): chr11:85996825-86003451:-
Subcellular localization: cytoplasm; exosome
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005575
MONDO name: colorectal cancer
Disease details: colorectal cancer
Disease DO ID:
 5672, 9256
Disease MeSH ID:
 -
Disease NCIt ID:
 C4978
Disease ICD11 ID:
 -
Disease OMIM ID:
 114500
Species: Human
Species details: Homo sapiens
Tissue specimen:

tumor tissue specimens; tumor tissues; animal tissue samples
Cell lines:

primary CRC cells; CRC/5-Fu cells; CRC/5-Fu resistant strain
In vivo animal model:

patient-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: ICAM5, AGO2, PICALM
Associated microRNA: miR-197-5p
Biological function: promotes migration, invasion, tumor growth, EMT, stemness, drug efflux, and 5-Fu resistance; inhibits apoptosis in vivo
Molecular mechanism: circ-0023919 functions as an exosomal ceRNA and molecular sponge for miR-197-5p, relieving miR-197-5p-mediated inhibition of ICAM5 and upregulating ICAM5 expression to promote EMT-mediated 5-Fu resistance.
Biological pathway or process:

ceRNA regulation (promotes); EMT (promotes); migration (promotes); invasion (promotes); proliferation (promotes); apoptosis (inhibits); stemness (promotes); drug resistance (promotes); chemoresistance (promotes); metastasis (promotes)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; Actinomycin D / DRB Stability Assay; RNase R Treatment; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; FISH / smFISH; Clinical Sample Validation; ROC Analysis; Survival Analysis; Cohort Study; Transfection; CCK8; Transwell Assay; Wound Healing Assay; Flow Cytometry（Non-apoptosis/cycle）; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry); TUNEL; Bioinformatics Analysis; Luciferase Reporter Assay; RNA Pull-Down; RIP (RNA Immunoprecipitation)
Clinical significance:

circ-0023919 has diagnostic efficacy for 5-Fu resistance and high expression is significantly associated with poor prognosis; it is considered a potential therapeutic target for CRC treatment.
Description:

Tumor cell-derived exosomal circ-0023919 is upregulated in 5-Fu-resistant colorectal cancer cells and exosomes and is associated with poor prognosis and diagnostic value for 5-Fu resistance. Functionally, circ-0023919 promotes CRC cell migration, invasion, tumor growth, EMT, stemness, drug efflux, and chemoresistance. Mechanistically, it acts as a ceRNA sponge for miR-197-5p to increase ICAM5 expression, thereby promoting EMT-mediated 5-Fu resistance.
Confidence score:

0.898
Other information
Title:

Tumor cell exosome circ-0023919 promotes EMT through the miR-197-5p/ICAM5 axis and enhances the drug resistance of colorectal cancer to 5-fu.

Journal: Experimental cell research
Published: 2026
PubMed ID: 41397666
Study type:

combined biological and clinical study
Data availability: The authors do not have permission to share data.; Supplementary data to this article can be found online at https://doi.org/10.1016/j.yexcr.2025.114866.
Code availability: -