| Expression pattern: |
UP |
| Associated gene: |
FUBP1, FIR, MYC, USF2 |
| Associated microRNA: |
- |
| Biological function: |
promotes proliferation, migration, invasion, metastasis and tumorigenesis; inhibits apoptosis; promotes angiogenesis |
| Molecular mechanism: |
circACTN4 binds FUBP1 and competitively blocks FIR-FUBP1 interaction, activating MYC transcription; USF2 promotes circACTN4 biogenesis |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); apoptosis (inhibits); angiogenesis (promotes); cell cycle (promotes); other pathway/process (promotes) |
| Detected method: |
Q
H
M
|
| Validation methods: |
Microarray; RNase R Treatment; Sanger Sequencing; Back-Splice Junction PCR / divergent primers PCR; RT-qPCR; ISH (In Situ Hybridization); FISH / smFISH; Nuclear-Cytoplasmic Fractionation; Actinomycin D / DRB Stability Assay; Transfection; CCK8; EdU Staining; Colony Formation Assay; Wound Healing Assay; Transwell Assay; Cell Cycle Assay; Annexin V/PI Flow Cytometry; Western Blot; RIP (RNA Immunoprecipitation); RNA Pull-Down; Co-IP; ChIP / ChIP-seq; Luciferase Reporter Assay; IF (Immunofluorescence); IHC (Immunohistochemistry); H&E Staining; In Vivo Animal Model; Clinical Sample Validation; Cohort Study; Survival Analysis; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
circACTN4 expression was correlated with clinical stage and poor prognosis; ROC AUC 0.719 for BC screening; circACTN4 overexpression was an independent predictor of poor prognosis in BC patients (HR = 4.566) |
| Description: |
circACTN4 (hsa_circ_0050900), derived from ACTN4, is up-regulated in breast cancer tissues/cells and associates with advanced stage and poor prognosis. It localizes mainly in the nucleus and promotes proliferation, invasion and metastasis by binding FUBP1, blocking FIR-FUBP1 interaction, and activating MYC transcription; USF2 enhances circACTN4 biogenesis. |
| Confidence score: |
0.9058 |