| Expression pattern: |
UP |
| Associated gene: |
LARP1, Ago2 |
| Associated microRNA: |
miR-330-5p |
| Biological function: |
Promotes NSCLC cell growth, migration/invasion and glutamine metabolism; inhibits apoptosis; promotes tumor growth in vivo. |
| Molecular mechanism: |
ceRNA mechanism: circ-PDZD8 sponges miR-330-5p to increase LARP1 expression. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); glutaminolysis (promotes); other pathway/process (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Nuclear-Cytoplasmic Fractionation; RNase R Treatment; Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Western Blot; In Vivo Animal Model; H&E Staining; Clinical Sample Validation |
| Clinical significance: |
Circ-PDZD8 high expression is associated with advanced TNM stage and lymph node metastasis (Table 1). |
| Description: |
Circ-PDZD8 is up-regulated in NSCLC tissues and cell lines and mainly localizes to the cytoplasm. It promotes malignant phenotypes and glutamine metabolism by sponging miR-330-5p to increase LARP1 expression, thereby enhancing tumor growth in vitro and in a xenograft model. |
| Confidence score: |
0.7637 |