circRNA basic information
circBase ID: -
Name: mmu_circ_N4bp1
Synonym: circN4bp1
Host Gene: N4bp1
 
 
 
 
 
 
Disease basic information
MONDO ID: MONDO:0006502
Mondo Name: acute respiratory distress syndrome
Disease details:
 sepsis-induced ARDS
Disease DO ID: -
Disease MeSH ID: -
Disease NCIt ID: C3353
Disease ICD11 ID: 1189702844
Disease OMIM ID: -
Species: Mus musculus
Sample Source: animal tissue
circRNA-disease information
Expression pattern:
DN
Cell type: macrophage
Cell type details: alveolar macrophages
Detected method:
primary cell isolation + qRT-PCR
Description:

In CLP-induced ARDS mice, circN4bp1 knockdown reduced circN4bp1 expression in alveolar macrophages compared with vector-treated CLP mice and was associated with reduced lung injury and inflammatory macrophage activation.
Other information
Title:

CircN4bp1 Facilitates Sepsis-Induced Acute Respiratory Distress Syndrome through Mediating Macrophage Polarization via the miR-138-5p/EZH2 Axis.

Journal: Mediators of inflammation
Published: 2021
PubMed ID: 35002536
Data availability: -