circRNA basic information
circBase ID: hsa_circ_0004287
Name: hsa_circ_MALAT1
Synonym: circ4287
Host Gene: MALAT1
 
 
 
 
 
 
Disease basic information
MONDO ID: MONDO:0005083
Mondo Name: psoriasis
Disease details:
 psoriasis
Disease DO ID: 8893
Disease MeSH ID: D011565
Disease NCIt ID: C3346
Disease ICD11 ID: 63698555
Disease OMIM ID: -
Species: Homo sapiens
Sample Source: primary cell culture; animal tissue
circRNA-disease information
Expression pattern:
UP
Cell type: macrophage
Cell type details: macrophages; M1 macrophages
Detected method:
primary cell isolation + qRT-PCR; cell-type co-localization
Description:

The study reports hsa_circ_0004287 upregulation in psoriasis patient PBMCs and macrophage-enriched expression under inflammatory conditions. Macrophage-specific hsa_circ_0004287 overexpression ameliorated inflammation in an IMQ-induced psoriatic mouse model.
Other information
Title:

Hsa_circ_0004287 inhibits macrophage-mediated inflammation in an N6-methyladenosine-dependent manner in atopic dermatitis and psoriasis.

Journal: The Journal of allergy and clinical immunology
Published: 2022
PubMed ID: 34953789
Data availability: GSE168694; GSE168696