circRNA basic information
circBase ID: hsa_circ_0004287
Name: hsa_circ_MALAT1
Synonym: circ4287
Host Gene: MALAT1
 
 
 
 
 
 
Disease basic information
MONDO ID: MONDO:0004980
Mondo Name: atopic eczema
Disease details:
 atopic dermatitis
Disease DO ID: 3310
Disease MeSH ID: D003876
Disease NCIt ID: C3001
Disease ICD11 ID: 215767047
Disease OMIM ID: 603165
Species: Homo sapiens
Sample Source: patient tissue; primary cell culture
circRNA-disease information
Expression pattern:
UP
Cell type: macrophage
Cell type details: CD14 1 monocyte-derived macrophages; CD68 1 macrophages
Detected method:
primary cell isolation + qRT-PCR; cell-type co-localization
Description:

hsa_circ_0004287 is increased in human PBMC-derived macrophages after inflammatory stimulation and colocalizes with CD68+ macrophages in AD skin lesions. Functional experiments support an inhibitory role in M1 macrophage activation and skin inflammation.
Other information
Title:

Hsa_circ_0004287 inhibits macrophage-mediated inflammation in an N6-methyladenosine-dependent manner in atopic dermatitis and psoriasis.

Journal: The Journal of allergy and clinical immunology
Published: 2022
PubMed ID: 34953789
Data availability: GSE168694; GSE168696