circRNA basic information
circBase ID: -
Name: mmu_circ_Esyt2
Synonym: -
Host Gene: Esyt2
 
 
 
 
 
 
Disease basic information
MONDO ID: MONDO:0005311
Mondo Name: atherosclerosis
Disease details:
 atherosclerosis
Disease DO ID: 1936
Disease MeSH ID: D050197
Disease NCIt ID: C35768
Disease ICD11 ID: 109367356
Disease OMIM ID: -
Species: Mus musculus
Sample Source: animal tissue
circRNA-disease information
Expression pattern:
UP
Cell type: smooth muscle cell
Cell type details: VSMCs
Detected method:
cell-type co-localization
Description:

FISH combined with immunofluorescence showed that circEsyt2 was significantly upregulated in α-SMA+ VSMCs within atherosclerotic plaques in ApoE-/- mice compared with C57BL/6J controls. The study links this VSMC expression to vascular remodeling and VSMC functional regulation.
Other information
Title:

Circular RNA circEsyt2 regulates vascular smooth muscle cell remodeling via splicing regulation.

Journal: The Journal of clinical investigation
Published: 2021
PubMed ID: 34907911
Data availability: GSE133269