circRNA basic information
circBase ID: -
Name: hsa_circ_PTK2
Synonym: circPTK2
Host Gene: PTK2
 
 
 
 
 
 
Disease basic information
MONDO ID: MONDO:0005233
Mondo Name: non-small cell lung carcinoma
Disease details:
 non-small cell lung cancer / NSCLC
Disease DO ID: 3908
Disease MeSH ID: D002289
Disease NCIt ID: C2926
Disease ICD11 ID: -
Disease OMIM ID: -
Species: Homo sapiens
Sample Source: patient tissue
circRNA-disease information
Expression pattern:
UP
Cell type: macrophage
Cell type details: M2 macrophages
Detected method:
primary cell isolation + qRT-PCR
Description:

circPTK2 was enriched in M2-like macrophage subpopulations isolated from NSCLC patient samples, with enrichment observed in primary lung and metastatic lymph node/blood regions.
Other information
Title:

Kras-driven intratumoral heterogeneity triggers infiltration of M2 polarized macrophages via the circHIPK3/PTK2 immunosuppressive circuit.

Journal: Scientific reports
Published: 2021
PubMed ID: 34326381
Data availability: -