circRNA basic information
circBase ID: hsa_circ_0000284
Name: hsa_circ_HIPK3
Synonym: circHIPK3
Host Gene: HIPK3
 
 
 
 
 
 
Disease basic information
MONDO ID: MONDO:0008383
Mondo Name: rheumatoid arthritis
Disease details:
 rheumatoid arthritis
Disease DO ID: 7148
Disease MeSH ID: D001172
Disease NCIt ID: C2884
Disease ICD11 ID: 576319925
Disease OMIM ID: 180300
Species: Homo sapiens
Sample Source: primary cell culture
circRNA-celltype information
Expression pattern:
UP
Cell type: fibroblast
Cell type details: RA fibroblast-like synoviocytes
Detected method:
primary cell isolation + qRT-PCR
Description:

circHIPK3 was up-regulated in RA fibroblast-like synoviocytes after TNF-α induction compared with control RA-FLS. Knockdown of circHIPK3 reduced VEGF production and impaired RA-FLS-induced angiogenesis.
Other information
Title:

Angiogenesis is Inhibited by Arsenic Trioxide Through Downregulation of the CircHIPK3/miR-149-5p/FOXO1/VEGF Functional Module in Rheumatoid Arthritis.

Journal: Frontiers in pharmacology
Published: 2021
PubMed ID: 34776969
Data availability: -