circRNA basic information
circBase ID: mmu_circ_0001572
Name: mmu_circ_Ube3a
Synonym: -
Host Gene: Ube3a
 
 
 
 
 
 
Disease basic information
MONDO ID: MONDO:0004781
Mondo Name: acute myocardial infarction
Disease details:
 acute myocardial infarction
Disease DO ID: 9408
Disease MeSH ID: -
Disease NCIt ID: C35204
Disease ICD11 ID: 1334938734
Disease OMIM ID: -
Species: Mus musculus
Sample Source: primary cell culture
circRNA-disease information
Expression pattern:
UP
Cell type: macrophage
Cell type details: M2 macrophages (M2Ms)
Detected method:
primary cell isolation + qRT-PCR
Description:

circUbe3a was elevated in M2 macrophage-derived small extracellular vesicles compared with M0 macrophage-derived small extracellular vesicles, based on circRNA microarray screening and RT-qPCR confirmation after primary macrophage isolation and polarization. Functional experiments supported that M2M-SEV-derived circUbe3a mediates communication with cardiac fibroblasts and promotes fibrosis-related fibroblast changes.
Other information
Title:

CircUbe3a from M2 macrophage-derived small extracellular vesicles mediates myocardial fibrosis after acute myocardial infarction.

Journal: Theranostics
Published: 2021
PubMed ID: 33995660
Data availability: -