circRNA basic information
circBase ID: mmu_circ_0001052
Name: mmu_circ_Hipk3
Synonym: circHIPK3
Host Gene: Hipk3
 
 
 
 
 
 
Disease basic information
MONDO ID: MONDO:0004994
Mondo Name: cardiomyopathy
Disease details:
 diabetic cardiomyopathy
Disease DO ID: 0050700
Disease MeSH ID: D009202
Disease NCIt ID: C34830
Disease ICD11 ID: 282225286
Disease OMIM ID: -
Species: Mus musculus
Sample Source: primary cell culture
circRNA-celltype information
Expression pattern:
UP
Cell type: fibroblast
Cell type details: cardiac fibroblasts
Detected method:
primary cell isolation + qRT-PCR
Description:

In primary mouse cardiac fibroblast culture, circHIPK3 was upregulated after high glucose or Ang II treatment. circHIPK3 knockdown suppressed Ang II-induced fibroblast proliferation and reduced COL1A1 and COL3A1 expression.
Other information
Title:

Involvement of circHIPK3 in the pathogenesis of diabetic cardiomyopathy in mice.

Journal: Diabetologia
Published: 2021
PubMed ID: 33398455
Data availability: -