circRNA basic information
circBase ID: -
Name: mmu_circ_HIPK2
Synonym: circ-HIPK2
Host Gene: HIPK2
 
 
 
 
 
 
Disease basic information
MONDO ID: MONDO:0024643
Mondo Name: myocardial disorder
Disease details:
 myocardial oxidative injury
Disease DO ID: -
Disease MeSH ID: -
Disease NCIt ID: C35544
Disease ICD11 ID: -
Disease OMIM ID: -
Species: Mus musculus
Sample Source: animal tissue; primary cell culture
circRNA-disease information
Expression pattern:
UP
Cell type: cardiomyocyte
Cell type details: primary mouse neonatal cardiomyocytes (MNCs)
Detected method:
primary cell isolation + qRT-PCR
Description:

circ-HIPK2 was up-regulated in H2O2-treated primary mouse neonatal cardiomyocytes as measured by RT-qPCR after primary cardiomyocyte isolation. Functional experiments in MNCs showed circ-HIPK2 promoted apoptosis and affected proliferation through the miR-485-5p/ATG101 axis.
Other information
Title:

Circ-HIPK2 Accelerates Cell Apoptosis and Autophagy in Myocardial Oxidative Injury by Sponging miR-485-5p and Targeting ATG101.

Journal: Journal of cardiovascular pharmacology
Published: 2020
PubMed ID: 33027196
Data availability: -