circRNA basic information
circBase ID: hsa_circ_0072688
Name: hsa_circ_ADAMTS6
Synonym: circ_0072688
Host Gene: ADAMTS6
 
 
 
 
 
 
Disease basic information
MONDO ID: MONDO:0005002
Mondo Name: chronic obstructive pulmonary disease
Disease details:
 smoking-related emphysema
Disease DO ID: 3083
Disease MeSH ID: D029424
Disease NCIt ID: C3199
Disease ICD11 ID: 133207228
Disease OMIM ID: 606963
Species: Homo sapiens
Sample Source: primary cell culture
circRNA-disease information
Expression pattern:
UP
Cell type: macrophage
Cell type details: macrophages
Detected method:
primary cell isolation + qRT-PCR
Description:

circADAMTS6 is up-regulated in CSE-treated macrophages, including primary BMDMs, in a concentration-dependent manner. Functional experiments indicate that circADAMTS6 participates in CSE-induced M2 macrophage polarization and proteinase/anti-proteinase imbalance.
Other information
Title:

circADAMTS6 via stabilizing CAMK2A is involved in smoking-induced emphysema through driving M2 macrophage polarization.

Journal: Environment international
Published: 2024
PubMed ID: 38936066
Data availability: -