circRNA basic information
circBase ID: hsa_circ_0005589
Name: hsa_circ_ARCN1
Synonym: circARCN1
Host Gene: ARCN1
 
 
 
 
 
 
Disease basic information
MONDO ID: MONDO:0005311
Mondo Name: atherosclerosis
Disease details:
 atherosclerosis
Disease DO ID: 1936
Disease MeSH ID: D050197
Disease NCIt ID: C35768
Disease ICD11 ID: 109367356
Disease OMIM ID: -
Species: Homo sapiens
Sample Source: patient tissue
circRNA-celltype information
Expression pattern:
UP
Cell type: macrophage
Cell type details: CD68 + macrophages
Detected method:
cell-type co-localization
Description:

circARCN1 is mainly localized in CD68+ macrophages within human atherosclerotic plaques, compared with endothelial cells and smooth muscle cells. The study links macrophage-expressed circARCN1 to plaque inflammation through the HuR-USP31-NF-κB axis.
Other information
Title:

CircARCN1 aggravates atherosclerosis by regulating HuR-mediated USP31 mRNA in macrophages.

Journal: Cardiovascular research
Published: 2024
PubMed ID: 39028686
Data availability: -