circRNA basic information
circBase ID: mmu_circ_0001052
Name: mmu_circ_Hipk3
Synonym: circHIPK3
Host Gene: Hipk3
 
 
 
 
 
 
Disease basic information
MONDO ID: MONDO:0005266
Mondo Name: diabetic retinopathy
Disease details:
 diabetic retinopathy
Disease DO ID: 8947
Disease MeSH ID: D003930
Disease NCIt ID: C34538
Disease ICD11 ID: 1006882070
Disease OMIM ID: -
Species: Mus musculus
Sample Source: primary cell culture
circRNA-celltype information
Expression pattern:
UP
Cell type: endothelial cell
Cell type details: retinal endothelial cells
Detected method:
primary cell isolation + qRT-PCR
Description:

circHIPK3 is up-regulated in retinal endothelial cells after high-glucose treatment mimicking diabetic conditions. Functional experiments in HRVECs showed that circHIPK3 regulates endothelial viability, proliferation, migration, and tube formation.
Other information
Title:

Circular Noncoding RNA HIPK3 Mediates Retinal Vascular Dysfunction in Diabetes Mellitus.

Journal: Circulation
Published: 2017
PubMed ID: 28860123
Data availability: -