circRNA basic information
circBase ID: hsa_circ_0002082
Name: hsa_circ_MALAT1
Synonym: circ‐MALAT1
Host Gene: MALAT1
 
 
 
 
 
 
Disease basic information
MONDO ID: MONDO:0007256
Mondo Name: hepatocellular carcinoma
Disease details:
 hepatocellular carcinoma
Disease DO ID: 684, 686
Disease MeSH ID: D006528
Disease NCIt ID: C3099
Disease ICD11 ID: 1294035808
Disease OMIM ID: 114550
Species: Homo sapiens
Sample Source: patient tissue; primary cell culture
circRNA-disease information
Expression pattern:
UP
Cell type: cancer stem cell
Cell type details: hepatocellular CSCs
Detected method:
primary cell isolation + RNA-seq; primary cell isolation + qRT-PCR
Description:

circ‐MALAT1 / hsa_circ_0002082 is up-regulated in hepatocellular cancer stem cells compared with matched adherent HCC cells, supported by circRNA-seq of patient-derived primary samples and qRT-PCR validation. The paper reports that circ‐MALAT1 promotes hepatocellular CSC self-renewal.
Other information
Title:

Circ-MALAT1 Functions as Both an mRNA Translation Brake and a microRNA Sponge to Promote Self-Renewal of Hepatocellular Cancer Stem Cells.

Journal: Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Published: 2020
PubMed ID: 32099751
Data availability: -