circRNA basic information
circBase ID: -
Name: mmu_circ_Hipk2
Synonym: circHIPK2 / circHipk2
Host Gene: Hipk2
 
 
 
 
 
 
Disease basic information
MONDO ID: MONDO:0005527
Mondo Name: toxic encephalopathy
Disease details:
 methamphetamine-induced neurotoxicity
Disease DO ID: 3602
Disease MeSH ID: D020258
Disease NCIt ID: C27961
Disease ICD11 ID: -
Disease OMIM ID: -
Species: Mus musculus
Sample Source: primary cell culture
circRNA-disease information
Expression pattern:
UP
Cell type: astrocyte
Cell type details: primary mouse astrocytes
Detected method:
primary cell isolation + qRT-PCR
Description:

circHIPK2 was detected in primary mouse astrocytes and was significantly increased after methamphetamine treatment by qRT-PCR using divergent primers. Knockdown studies linked circHIPK2 to astrocyte activation, autophagy, and ER stress in astrocytes.
Other information
Title:

Circular RNA HIPK2 regulates astrocyte activation via cooperation of autophagy and ER stress by targeting MIR124-2HG.

Journal: Autophagy
Published: 2017
PubMed ID: 28786753
Data availability: -