circRNA basic information
circBase ID: -
Name: -
Synonym: circSPECC1
Host Gene: SPECC1
 
 
 
 
 
 
Disease basic information
MONDO ID: MONDO:0000960
Mondo Name: diabetic peripheral angiopathy
Disease details:
 diabetes-induced microvascular dysfunction
Disease DO ID: 11713
Disease MeSH ID: D003925
Disease NCIt ID: C35610
Disease ICD11 ID: -
Disease OMIM ID: -
Species: Mus musculus
Sample Source: primary cell culture
circRNA-celltype information
Expression pattern:
UP
Cell type: macrophage
Cell type details: bone marrow-derived monocytes (BMDMs)
Detected method:
primary cell isolation + qRT-PCR
Description:

cSPECC1 expression is increased in isolated BMDMs after high-glucose diabetic stress. The study further links cSPECC1 in macrophages to macrophage polarization and macrophage-endothelial crosstalk.
Other information
Title:

Macrophage metabolic reprogramming ameliorates diabetes-induced microvascular dysfunction.

Journal: Redox biology
Published: 2025
PubMed ID: 39647239
Data availability: -