circRNA basic information
circBase ID: hsa_circ_0000284
Name: hsa_circ_HIPK3
Synonym: -
Host Gene: HIPK3
 
 
 
 
 
 
Disease basic information
MONDO ID: MONDO:0005380
Mondo Name: osteonecrosis
Disease details:
osteonecrosis
Disease DO ID: 0080008, 10159
Disease MeSH ID: D010020
Disease NCIt ID: C34880; C35476
Disease ICD11 ID: 536467755
Disease OMIM ID: -
Species: Homo sapiens
Sample Source: primary cell culture
circRNA-disease information
Expression pattern:
DN
Cell type: osteoblast
Cell type details: primary human osteoblasts
Detected method:
primary cell isolation + qRT-PCR
Description:

circHIPK3 expression is downregulated in primary human osteoblasts after dexamethasone treatment compared with untreated control cells. Functional experiments in primary human osteoblasts showed that circHIPK3 overexpression attenuated DEX-induced viability reduction, cell death, apoptosis, and mitochondrial injury, while circHIPK3 silencing potentiated DEX-induced cytotoxicity.

Other information
Title:

Dexamethasone-induced cytotoxicity in human osteoblasts is associated with circular RNA HIPK3 downregulation.

Journal: Biochemical and biophysical research communications
Published: 2019
PubMed ID: 31242973
Data availability: -