circRNA basic information
circBase ID: hsa_circ_0047713
Name: hsa_circ_SMAD4
Synonym: circSMAD4
Host Gene: SMAD4
 
 
 
 
 
 
Disease basic information
MONDO ID: MONDO:0005061
Mondo Name: lung adenocarcinoma
Disease details:
 lung adenocarcinoma
Disease DO ID: 3910
Disease MeSH ID: C538231
Disease NCIt ID: C3512
Disease ICD11 ID: -
Disease OMIM ID: -
Species: Homo sapiens
Sample Source: patient tissue
circRNA-disease information
Expression pattern:
UP
Cell type: macrophage
Cell type details: tumor-associated macrophages / TAMs
Detected method:
cell sorting + RNA-seq; cell sorting + qRT-PCR; cell-type co-localization
Description:

circSMAD4 / hsa_circ_0047713 is enriched in sorted LUAD tumor-associated macrophages compared with normal tissue-resident macrophages, with additional CD68 co-localization support in tumor sections. Functional experiments indicate that circSMAD4 promotes tumor-educated M2-like, matrix-remodeling macrophage programs and downstream protumor effects.
Other information
Title:

CircSMAD4 shapes matrix-remodeling TAMs in lung adenocarcinoma.

Journal: Non-coding RNA research
Published: 2026
PubMed ID: 41940034
Data availability: -