circRNA basic information
circBase ID: mmu_circ_0001052
Name: mmu_circ_HIPK3
Synonym: circHIPK3
Host Gene: HIPK3
 
 
 
 
 
 
Disease basic information
MONDO ID: MONDO:0005267
Mondo Name: heart disorder
Disease details:
 cardiac fibrosis
Disease DO ID: 114
Disease MeSH ID: D006331
Disease NCIt ID: C3079
Disease ICD11 ID: 1512587470
Disease OMIM ID: -
Species: Mus musculus
Sample Source: animal tissue; primary cell culture
circRNA-celltype information
Expression pattern:
UP
Cell type: fibroblast
Cell type details: CFs
Detected method:
primary cell isolation + qRT-PCR
Description:

circHIPK3 is up-regulated in cardiac fibroblasts after Ang II or TGF-β treatment and in cardiac fibroblasts isolated from Ang II pump-treated mouse hearts compared with saline controls. Functional experiments in CFs showed that circHIPK3 regulates proliferation, migration and fibrosis-associated marker expression.
Other information
Title:

Inhibition of circHIPK3 prevents angiotensin II-induced cardiac fibrosis by sponging miR-29b-3p.

Journal: International journal of cardiology
Published: 2019
PubMed ID: 30967276
Data availability: -