circRNA basic information
circBase ID: -
Name: mmu_circ_HIPK2
Synonym: -
Host Gene: HIPK2
 
 
 
 
 
 
Disease basic information
MONDO ID: MONDO:0006663
Mondo Name: perinatal asphyxia
Disease details:
 neonatal hypoxic-ischemic encephalopathy
Disease DO ID: 11088
Disease MeSH ID: D001238
Disease NCIt ID: C116313
Disease ICD11 ID: 1281282034
Disease OMIM ID: -
Species: Mus musculus
Sample Source: primary cell culture
circRNA-disease information
Expression pattern:
DN
Cell type: astrocyte
Cell type details: primary astrocytes
Detected method:
primary cell isolation + qRT-PCR
Description:

In isolated and cultured primary mouse astrocytes, qRT-PCR showed that circHIPK2 siRNAs reduced circHIPK2 expression compared with untreated control cells, with siRNA-3 producing an 80.13% decrease. The study links astrocyte-targeted circHIPK2 silencing to reduced astrocyte activation and neuroinflammation in HIE/HIBD models.
Other information
Title:

Dual-Modified Mannose/RVG29 Peptide-Functionalized Lipid Nanoparticles Loaded With circHIPK2 siRNA Ameliorate Hypoxic-Ischemic Brain Damage in Neonatal Mice by Suppressing Astrocyte Activation.

Journal: Journal of integrative neuroscience
Published: 2025
PubMed ID: 41503997
Data availability: -