circRNA basic information
circBase ID: hsa_circ_0002483
Name: hsa_circ_PTK2
Synonym: -
Host Gene: PTK2
 
 
 
 
 
 
Disease basic information
MONDO ID: MONDO:0002771
Mondo Name: pulmonary fibrosis
Disease details:
 pulmonary fibrosis
Disease DO ID: 3770
Disease MeSH ID: D011658
Disease NCIt ID: C26869
Disease ICD11 ID: -
Disease OMIM ID: -
Species: Homo sapiens
Sample Source: patient tissue
circRNA-disease information
Expression pattern:
UP
Cell type: fibroblast
Cell type details: fibroblast
Detected method:
cell-type co-localization
Description:

circPTK2/circPTK2-m + is upregulated in fibroblast-marker-positive lung tissue regions from pulmonary fibrosis patients versus non-diseased controls, supported by fluorescent co-staining with vimentin. Functional experiments in fibroblasts indicate that circPTK2-m + promotes fibroblast activation, proliferation, and migration.
Other information
Title:

Methylated circPTK2 as a driver of fibroblast activation in pulmonary fibrosis.

Journal: Molecular therapy : the journal of the American Society of Gene Therapy
Published: 2026
PubMed ID: 41376162
Data availability: -