circRNA basic information
circBase ID: hsa_circ_0006646
Name: hsa_circ_PTK2
Synonym: circ_0006646
Host Gene: PTK2
 
 
 
 
 
 
Disease basic information
MONDO ID: MONDO:0005178
Mondo Name: osteoarthritis
Disease details:
 Osteoarthritis
Disease DO ID: 8398
Disease MeSH ID: D010003
Disease NCIt ID: C3293
Disease ICD11 ID: 558562409
Disease OMIM ID: -
Species: Homo sapiens
Sample Source: primary cell culture
circRNA-disease information
Expression pattern:
UP
Cell type: chondrocyte
Cell type details: human chondrocytes
Detected method:
primary cell isolation + qRT-PCR
Description:

circ_0006646 was up-regulated in primary human chondrocytes treated with IL-1β compared with untreated chondrocytes. Knockdown of circ_0006646 modulated proliferation, apoptosis, inflammation, and ECM degradation in IL-1β-treated chondrocytes.
Other information
Title:

Circ_0006646 Promotes the Progression of Osteoarthritis via Upregulating CDH11 Expression in an IGF2BP2-Dependent Manner.

Journal: The Kaohsiung journal of medical sciences
Published: 2025
PubMed ID: 40387410
Data availability: -