circRNA basic information
circBase ID: mmu_circ_0000693
Name: mmu_circ_Dcbld2
Synonym: circDcbld2
Host Gene: Dcbld2
 
 
 
 
 
 
Disease basic information
MONDO ID: MONDO:0005155
Mondo Name: cirrhosis of liver
Disease details:
 hepatic fibrosis
Disease DO ID: 5082
Disease MeSH ID: D008103
Disease NCIt ID: C2951
Disease ICD11 ID: -
Disease OMIM ID: -
Species: Mus musculus
Sample Source: primary cell culture
circRNA-disease information
Expression pattern:
UP
Cell type: macrophage
Cell type details: BMDMs
Detected method:
primary cell isolation + qRT-PCR
Description:

circDcbld2 was significantly elevated in bone marrow-derived macrophages in hepatic fibrosis. In BMDMs, circDcbld2 silencing reduced LPS-induced inflammation and oxidative stress and decreased HSC activation in co-culture experiments.
Other information
Title:

N 6-Methyladenosine modification of circDcbld2 in Kupffer cells promotes hepatic fibrosis via targeting miR-144-3p/Et-1 axis.

Journal: Acta pharmaceutica Sinica. B
Published: 2025
PubMed ID: 40041896
Data availability: -