circRNA basic information
circBase ID: hsa_circ_0058495
Name: hsa_circ_RHBDD1
Synonym: circRHBDD1
Host Gene: RHBDD1
 
 
 
 
 
 
Disease basic information
MONDO ID: MONDO:0005184
Mondo Name: pancreatic ductal adenocarcinoma
Disease details:
 pancreatic ductal adenocarcinoma
Disease DO ID: 3498, 3587
Disease MeSH ID: D021441
Disease NCIt ID: C9120
Disease ICD11 ID: 581089833
Disease OMIM ID: -
Species: Homo sapiens
Sample Source: patient tissue
circRNA-celltype information
Expression pattern:
UP
Cell type: macrophage
Cell type details: M2 macrophages
Detected method:
cell-type co-localization
Description:

FISH evidence in patient-derived PDAC tissues showed that hsa_circ_0058495 was abundant in M2 macrophages, and the authors reported higher abundance in M2 macrophages than M1 macrophages. Exosomal hsa_circ_0058495 was reported to facilitate M2 macrophage polarization through the IGF2BP2-MEKK1 axis.
Other information
Title:

Hsa_circ_0058495-mediated IGF2BP2 ubiquitination and m6A modification of MEKK1 promote the progression of PDAC.

Journal: Theranostics
Published: 2025
PubMed ID: 41041073
Data availability: -