circRNA basic information
circBase ID: mmu_circ_0001052
Name: mmu_circ_Hipk3
Synonym: CircHipk3
Host Gene: Hipk3
 
 
 
 
 
 
Disease basic information
MONDO ID: MONDO:0005350
Mondo Name: abdominal aortic aneurysm
Disease details:
 abdominal aortic aneurysm
Disease DO ID: 7693
Disease MeSH ID: D017544
Disease NCIt ID: -
Disease ICD11 ID: 1154633768
Disease OMIM ID: -
Species: Mus musculus
Sample Source: patient tissue; animal tissue
circRNA-disease information
Expression pattern:
UP
Cell type: macrophage
Cell type details: macrophage
Detected method:
cell-type co-localization
Description:

circHipk3 is increased in CD68-positive macrophages in AAA samples compared with normal/non-diseased aorta, supported by co-staining in murine and human aortic tissues. The study links circHipk3 in macrophages to pyroptosis and inflammatory mediator/MMP induction in AAA.
Other information
Title:

CircHipk3 serves a dual role in macrophage pyroptosis by promoting NLRP3 transcription and inhibition of autophagy to induce abdominal aortic aneurysm formation.

Journal: Clinical and translational medicine
Published: 2024
PubMed ID: 39601144
Data availability: -