circRNA basic information
circBase ID: mmu_circ_0000693
Name: mmu_circ_Dcbld2
Synonym: circDcbld2
Host Gene: Dcbld2
 
 
 
 
 
 
Disease basic information
MONDO ID: MONDO:0005155
Mondo Name: cirrhosis of liver
Disease details:
 hepatic fibrosis
Disease DO ID: 5082
Disease MeSH ID: D008103
Disease NCIt ID: C2951
Disease ICD11 ID: -
Disease OMIM ID: -
Species: Mus musculus
Sample Source: animal tissue
circRNA-celltype information
Expression pattern:
UP
Cell type: macrophage
Cell type details: KCs
Detected method:
primary cell isolation + RNA-seq
Description:

circDcbld2 was up-regulated in isolated Kupffer cells from mouse hepatic fibrosis models compared with controls, based on circRNA high-throughput sequencing. Functional evidence indicates circDcbld2 affects KC inflammatory factor production and HSC activation via the miR-144-3p/Et-1 axis.
Other information
Title:

N 6-Methyladenosine modification of circDcbld2 in Kupffer cells promotes hepatic fibrosis via targeting miR-144-3p/Et-1 axis.

Journal: Acta pharmaceutica Sinica. B
Published: 2025
PubMed ID: 40041896
Data availability: -