circRNA basic information
circBase ID: -
Name: hsa_circ_METTL3
Synonym: circMETTL3
Host Gene: METTL3
 
 
 
 
 
 
Disease basic information
MONDO ID: MONDO:0015542
Mondo Name: secondary hemophagocytic lymphohistiocytosis
Disease details:
 Secondary Hemophagocytic lymphohistiocytosis
Disease DO ID: -
Disease MeSH ID: -
Disease NCIt ID: C121184
Disease ICD11 ID: -
Disease OMIM ID: -
Species: Homo sapiens
Sample Source: patient tissue
circRNA-disease information
Expression pattern:
UP
Cell type: macrophage
Cell type details: CD11b-labeled mononuclear macrophages
Detected method:
cell-type co-localization
Description:

circMETTL3 expression is increased in CD11b-labeled mononuclear macrophages from sHLH patients compared with healthy controls, supported by fluorescence colocalization. The study further links circMETTL3 to macrophage glycolysis and M1 polarization.
Other information
Title:

CircMETTL3-156aa reshapes the glycolytic metabolism of macrophages to promote M1 polarization and induce cytokine storms in sHLH.

Journal: Cell death discovery
Published: 2024
PubMed ID: 39384750
Data availability: -