circRNA basic information
circBase ID: -
Name: -
Synonym: mmu-circ-0034880
Host Gene: -
 
 
 
 
 
 
Disease basic information
MONDO ID: MONDO:0005575
Mondo Name: colorectal cancer
Disease details:
 colorectal cancer
Disease DO ID: 5672, 9256
Disease MeSH ID: -
Disease NCIt ID: C4978
Disease ICD11 ID: -
Disease OMIM ID: 114500
Species: Mus musculus
Sample Source: primary cell culture
circRNA-disease information
Expression pattern:
UP
Cell type: macrophage
Cell type details: BMDMs
Detected method:
primary cell isolation + qRT-PCR
Description:

Primary mouse BMDMs showed increased circ-0034880 after co-culture with murine colon cancer cell-derived TEVs, while circ-0034880-silenced TEVs had minimal effect. The authors concluded that circ-0034880 was transferred to macrophages from cancer cells in TEVs and promoted CD206+ pro-tumor macrophage activation.
Other information
Title:

Targeting circ-0034880-enriched tumor extracellular vesicles to impede SPP1highCD206+ pro-tumor macrophages mediated pre-metastatic niche formation in colorectal cancer liver metastasis.

Journal: Molecular cancer
Published: 2024
PubMed ID: 39164758
Data availability: -