circRNA basic information
circBase ID: hsa_circ_0100519
Name: hsa_circ_EPSTI1
Synonym: circ‐0100519
Host Gene: EPSTI1
 
 
 
 
 
 
Disease basic information
MONDO ID: MONDO:0007254
Mondo Name: breast cancer
Disease details:
 breast cancer
Disease DO ID: 1612
Disease MeSH ID: -
Disease NCIt ID: C9335
Disease ICD11 ID: 1047754165
Disease OMIM ID: -
Species: Homo sapiens
Sample Source: patient tissue; cell line-derived model
circRNA-disease information
Expression pattern:
UP
Cell type: macrophage
Cell type details: macrophages
Detected method:
cell-type co-localization
Description:

Breast cancer cell-derived exosomal circ‐0100519 was detected in macrophages and was shown by cell-type co-localization with macrophage markers in tumour sections. Elevated circ‐0100519 promoted M2-like macrophage polarization through the USP7/NRF2 axis.
Other information
Title:

Exosomal circ-0100519 promotes breast cancer progression via inducing M2 macrophage polarisation by USP7/NRF2 axis.

Journal: Clinical and translational medicine
Published: 2024
PubMed ID: 39107958
Data availability: -